MEDIBENA Life Science & Diagnostic Solutions | office@medibena.at | TEL: +43-699-1133-0065 | FAX: +43-1-2533-0339-577
call us

Free Shipping on orders over 250€

Order your preferred reagents from Medibena online shop or per E-mail: order@medibena.com

MagnetoFectionâ„¢

Magnetic nanoparticles for nucleic acids and small molecules delivery

  • This method associates nucleic acids or other vectors with magnetic nanoparticles coated with cationic molecules. The magnetic nanoparticles are made of iron oxyde, which is fully biodegradable, coated with specific cationic proprietary molecules varying upon applications. Their association with the gene vectors (DNA, siRNA, ODN, virus, etc.) is achieved by salt-induced colloidal aggregation and electrostatic interaction.

Intracellular uptake of nanoparticles

The resulting molecular complexes are then targeted to and endocyted by cells, supported by an appropriate magnetic field. Membrane architecture and structure stay intact in contrast to other physical transfection methods that damage, create hole or electroshock the cell membranes. In addition the magnetic nanobeads are completely biodegradable and not toxic at the recommended doses and even higher. In this manner, the complete applied vector dose gets concentrated on the cells within a few minutes. Consequently, 100% of the cells get in contact with a significant vector dose.

Intracellular release of vectors and drugs         

The nucleic acids or other vectors are then released into the cytoplasm by different mechanisms depending on the formulation used. One is the proton sponge effect caused by cationic polymers coated on the nanoparticles that promotes endosome osmotic swelling, disruption of the endosomal membrane and intracellular release of associated molecules. Second is the destabilization of the endosome by cationic lipids coated on the particles that release the vectors into cells by flip-flop of cell negative lipids and charged neutralization. Third one is the usual viral mechanism when virus is used.

Inspired by the validated and recognized magnetic drug targeting technology, this innovative method is a revolution for transfection and infection.

Several optimized reagents have been designed according to define applications:

Combination of CombiMag and Lipofectamine™2000 from Invitrogen™ to increase trasfection efficiency.

Magnetic cell purification and transduction all-in-one

A new reagent for all nucleic acids transfection

for enhancing all transfection reagents efficiency

for virus transduction

for adenovirus & AAV transduction  NEW

for siRNA applications

for Neurons transfection 

Items 1 to 10 of 15 total

per page
Page:
  1. 1
  2. 2

Set Descending Direction
  1. OZ_AM7-GP AdenoMag - Designed to increase virus infection

    AdenoMag - Designed to increase virus infection

    Call or Email for Price

    AdenoMag is a reagent dedicated to enhance Adenovirus and Adeno Associated Virus (AAV) infection. It allows to rapidly concentrate all viral particles onto cells. Learn More
  2. OZ_CM2-GP CombiMag - Enhance your transfection reagent efficiency

    CombiMag - Enhance your transfection reagent efficiency

    Call or Email for Price

    CombiMag reagent is the only existing method based on the use of magnetic nanoparticles (Magnetofection), for improving your transfection reagent efficiency. Learn More
  3. OZ_ET1-GP EcoTransfect - Economical reagent for routine transfection

    EcoTransfect - Economical reagent for routine transfection

    Call or Email for Price

    EcoTransfect is an economical reagent dedicated to the transfection of popular cell lines. It is the perfect solution to quickly analyze the biological activity of your nucleic acids, to perform routine transfection assays at low cost and to accomplish high throughput screening.

    Learn More
  4. OZ_IV-DM3-GP /

    In vivo DogtorMag

    Call or Email for Price

    In vivo DogtorMag is a cationic lipid-based magnetic nanoparticles formulation. It associates Dogtor a specific cationic lipid and CombiMag magnetic nanoparticles. This reagent is suitable for plasmid DNA, antisense oligonucleotides, mRNA and siRNA. Learn More
  5. OZ_IV-VM30-GP /

    In vivo ViroMag

    Call or Email for Price

    In vivo ViroMag is an optimized nanoparticles formulation dedicated to viral vectors. It is particularly suitable for Lentiviral/Retroviral, Adenoviral and Adeno-Associated Viral (AAV) vectors. Learn More
  6. OZ_LM80-GP LipoMag - A powerful  & unique transfection kit

    LipoMag - A powerful & unique transfection kit

    Call or Email for Price

    This new kit is an association of DreamFectâ„¢ Gold and CombiMag reagents. DreamFectâ„¢ Gold formulation is a lipofection reagent achieving high transfection efficiency and high transgene expression level. CombiMag is a Magnetofectionâ„¢ reagent: versatile and improving transfection efficiency without toxicity. The LipoMag Kit combines both of the advantages of lipofection and magnetofection transfection technique to transfect all kind of cells with the best efficiency! Learn More
  7. OZ_Mag4C-Ad-GP Mag4C Starter Kit

    Mag4C-Ad Kits

    Call or Email for Price

    Mag4C-Ad Kit is specifically designed and developed for capturing, concentrating and storing Adenoviruses. Learn More
  8. OZ_Mag4C-Lv-GP Mag4C Starter Kit

    Mag4C-LV Kits

    Call or Email for Price

    Mag4C-Lv Kit for magnetic capture, concentration and conservation of Lentiviruses and Retroviruses Learn More
  9. OZ_MTX-GP Magnetofectamineâ„¢ Transfection Kit

    Magnetofectamineâ„¢ Transfection Kit

    Call or Email for Price

    Ideal to transfect primary and Hard-to-transfect cells, Magnetofectamine™ associates Lipofectamine™ 2000 from Invitrogen™ and OZ Biosciences's CombiMag reagent, increasing the overall efficiency of your transfection while minimizing cytotoxicity.

    Learn More
  10. OZ_NM5-GP NeuroMag - transfection reagent for neurons

    NeuroMag - transfection reagent for neurons

    Call or Email for Price

    NeuroMag is the first dedicated Magnetofection â„¢ transfection reagent for neurons. It is perfect for primary neurons and can also be used with cell lines and glial cells. Learn More

Items 1 to 10 of 15 total

per page
Page:
  1. 1
  2. 2

Set Descending Direction
MEDIBENA Life Science & Diagnostic Solutions | Zeillergasse 38, 1170 Vienna, Austria, Europe | office@medibena.at | TEL: +43-699-1133-0065 | FAX: +43-1-2533-0339-577 | Skype: medibena | Register of companies: Handelsgericht Wien Österreich | FN: 392173a | VAT: ATU67954225 | EORI: ATEOS1000086649 | Dr. Monika Bencurova MEDIBENA Life Science E.U. | www.MEDIBENA.at