In vivo Magnetofectionâ„¢

We are very proud to announce the upcoming launch of the “In vivo Magnetofection” technology: The unique solution for in vivo targeted transfection / transduction.

This original system combines magnetic nanoparticles and nucleic acid vectors that will be retained after injection at the magnetically targeted site.
In this way, targeted delivery minimizes systemic distribution and reduces toxicity.
Furthermore, the magnetic force will enhance the uptake of magnetic nanoparticles by the target tissue, and thus improve the efficiency of transfection/transduction. This allows decreasing the required process time of delivery to few minutes which is crucial for improvement of in vivo nucleic acid delivery.

We offer three types of ready-to-use In vivo Magnetofection™ reagents

• In vivo PolyMag is a cationic polymer-based magnetic nanoparticles formulation. It can be used with plasmid DNA, antisense oligonucleotides, mRNA and siRNA.
• In vivo DogtorMag is a cationic lipid-based magnetic nanoparticles formulation. It associates Dogtor a specific cationic lipid and CombiMag magnetic nanoparticles. This reagent is suitable for plasmid DNA, antisense oligonucleotides, mRNA and siRNA.
• In vivo ViroMag is an optimized nanoparticles formulation dedicated to viral vectors. It is particularly suitable for Lentiviral/Retroviral, Adenoviral and Adeno-Associated Viral (AAV) vectors.

The principal In vivo MagnetoFection™ advantages

• Increased transfection/transduction efficiency
• Targeted process (magnetically-driven) / Penetration of the vector into tissues
• Reduction of the systemic dissemination of vectors during injection
• Reduction of the vector doses (nucleic acid, virus…)
• Work under non permissive conditions (hypothermia, physiological flow conditions)
• Minimized toxicity
• Universal – suitable for all nucleic acids or viral vectors